Publication
Representative Publications
- Xue, Y.#, Hou, X.#*, Wang, S., Zhang, Y., Zhong, Y., Kang, D. D., Wang C., Li, H., Yu, C., Liu, Z., Tian, M., Cao, D., Zheng Y.Y., Deng, B., Hamon, P., Merad, M., Dong. Y.* Antimicrobial peptide delivery to lung as peptibody mRNA in antinflammatory lipids treats multidrug-resistant bacterial pneumonia. Nature Biotechnology (2025). DOI: 10.1038/s41587-025-02928-x
- Xue, Y.#, Hou, X.#*, Zhong, Y.#, Zhang. Y., Du, S., Kang, D. D., Wang, L., Wang, C., L, H., Wang, S., Liu, Z., Tian, M., Guo, K., Cao, D., Deng, B., McComb, D. W., Purisic, E., Dai,J., Hamon, P., Brown, B. D., Tsankova, N., M, Merad, M., Irvine, D. J., Weiss, R., Dong, Y*. LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment. Nature Communications (2025).
- Cao, D.#, Hou, X.#, Wang, C.#, Wang, S.#, Liu, Z., Tian, M., Guo, K., Li, H., Kang, D. D., Zhong, Y., Xue, Y., Yu. C., Deng, B., Dong, Y.* Lipid nanoparticles for mRNA delivery in brain via systemic administration. Science Advances (2025). DOI: 10.1126/sciadv.adw0730
- Zhang, Y.#, Hou, X.#, Du, S., Xue, Y., Yan, J., Kang, D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.* Close the cancer-immunity cycle by integrating lipid nanoparticle-mRNA formulations and dendritic cell therapy. Nature Nanotechnology (2023). DOI: 10.1038/s41565-023-01453-9
- Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.* Lipid nanopartices for mRNA delivery. Nature Reviews Materials (2021).
- Hou, X.#, Zhang. X.#, Zhao, W., Zeng, C., Deng B., McComb, D. W., Du, S., Zhang, C., Li, W., Dong. Y.* Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nature Nanotechnology (2020). DOI: 10.1038/s41565-019-0600-1
Publications
2026
Zhou, M., Chen, J., Zheng, Z., Du, S.*, Hou, X.* How has the inclusion of unconventional lipids improved LNP-mediated mRNA delivery? Nanomedicine (2026).
Li, H., Wang, L., Zhong, Y., Guo, K., Xue, Y., Wang, C., Wang, S., Hou, X., Chen, D. S., Liu, Z., Cao, D., Tian, M., Kang, D. D., Mu, X., Deng. B., McComb, D. W., Taouli, B., Brown, B. D., Dong, Y.* mRNA-based MRI contrast agent for precise diagnosis of glioma and pseudoprogression. Cell Biomaterials (2026).
2025
Xue, Y.#, Hou, X.#*, Wang, S., Zhang, Y., Zhong, Y., Kang, D. D., Wang C., Li, H., Yu, C., Liu, Z., Tian, M., Cao, D., Zheng Y.Y., Deng, B., Hamon, P., Merad, M., Dong. Y.* Antimicrobial peptide delivery to lung as peptibody mRNA in antinflammatory lipids treats multidrug-resistant bacterial pneumonia. Nature Biotechnology (2025). DOI: 10.1038/s41587-025-02928-x
Cao, D.#, Hou, X.#, Wang, C.#, Wang, S.#, Liu, Z., Tian, M., Guo, K., Li, H., Kang, D. D., Zhong, Y., Xue, Y., Yu. C., Deng, B., Dong, Y.* Lipid nanoparticles for mRNA delivery in brain via systemic administration. Science Advances (2025). DOI: 10.1126/sciadv.adw0730
Hou, X.#, Wang, C.#, Zhong. Y.#, Wang, L.#, Kang, D.D., Lubitz, G., Xue, Y., Liu, Z., Wang, S., Li, H., Tian, M., Cao, D., Guo, K., Deng, B., McComb, D.W., Marron, T., Brown, B.D., Merad, M., Brody, J.D.*, Dong, Y.* Enhancing antitumor immunity throughchemotherapeutic-derived lipid nanoparticle -induced immunogenic cell death and CD40L/FIt3L mRNA-mediated dendritic cellactivation. Journal of Controlled Release (2025). DOI: 10.1016/j.jconrel.2025.113684
Xue, Y.#, Hou, X.#*, Zhong, Y.#, Zhang. Y., Du, S., Kang, D. D., Wang, L., Wang, C., L, H., Wang, S., Liu, Z., Tian, M., Guo, K., Cao, D., Deng, B., McComb, D. W., Purisic, E., Dai,J., Hamon, P., Brown, B. D., Tsankova, N., M, Merad, M., Irvine, D. J., Weiss, R., Dong, Y*. LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment. Nature Communications (2025). DOI: 10.1038/s41467-025-57149-2
Li, H, Zhang, Y., Zhong, Y. Guo, K, Du, S, Xue, Y, Wang, C., Wang, S, Chen, D.S., Liu, Z., Cao, D., Tian, M., Yu, C., Kang, D. D., Hou, X., Deng, B., McComb, D. W., Thatikonda, S. K., Yen, C. W.*, Dong, Y*. Aminophosphonate-Derived lipid nanoparticles enable circular RNA delivery for functional recovery after spinal cord injury. Materials Today (2025). DOI: 10.1016/j.mattod.2025.10.005
Xue, Y.#, Wang. C.#, Li, H.#, Du, S., Zhong. Y., Zhang, Y., Wang, S., Guo, K., Hou, X., Kang, D.D. Liu, Z., Tian, M., Cao, D., Deng, B., McComb, D.W., Markovic, T., Pan, J., Borna, M., Nestler, E.J., Peng, P.C., Dong, Y.* Lipid nanoparticles enhance mRNA delivery to the central nervous system upon intrathecal injection. Advanced Materials (2025). DOI: 10.1002/adma.202417097
Liu, Z., Zhang, Y., Li, H., Guo, K., Tian, M., Cao, D., Kang, D.D., Xue, Y., Hou, X., Wang, C., Wang, S., Zhong, Y., Yu, C., Deng, B., McComb D.W., Dong Y.* Furan-derived lipid nanoparticles for transporting mRNA to the central nervous system. Journal of the American Chemical Society (2025). DOI: 10.1021/jacs.4c16326
Wang. C.#, Xue, Y.#, Markovic, T.#, Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., Liu, Z., Tian, M., Kang, D.D., Wang, L., Guo, K., Cao. D., Yan, J., Deng. B., McComb, D.W., Parsons, R.E., Minier-Toribio, A.M., Holt, L.M., Pan, J., Hashemi, A., Kopell, B.H., Charney. A.W., Nestler, E.J.*, Peng, P.C.*, Dong. Y.* Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials (2025). DOI: 10.1038/s41563-024-02114-5
2024
Kang, D. D.#, Hou, X.#*, Wang, L., Xue, Y., Li, H., Zhong, Y., Wang, S., Deng, B., McComb, D., Dong, Y.* Engineering LNPs with polysarcosine lipids for mRNA delivery. Bioactive Materials (2024). DOI: 10.1016/j.bioactmat.2024.03.017
Yan, J.#, Kang, D. D.#, Wang, C.#, Hou, X., Du, S., Wang, S., Xue, Y., Liu, Z., Li, H., Zhong, Y., Deng, B., McComb, D. W., & Dong, Y.* LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities. Nano Research (2024). DOI: 10.1007/s12274-024-6747-6
Wang, C.#, Wang, S.#, Xue, Y., Zhong, Y., Li, H., Hou, X., Kang, D.D., Liu, Z., Tian, M., Wang, L., Cao, D., Yu, Y., Liu, J., Cheng, X., Markovic, T., Hashemi, A., Kopell, B.H., Charney, A.W., Nestler, E.J.*, Dong, Y.*, Intravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system. Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02487-7
Wang, S.#, Zhang, Y.#, Zhong, Y.#, Xue, Y., Liu, Z., Wang, C., Kang, D. D., Li, H., Hou, X., Tian, M., Cao, D., Wang, L., Guo, K., Deng, B., McComb, D. W., Merad, M., Brown, B. D., Dong, Y.* Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proceedings of the National Academy of Sciences of the United States of America (2024). DOI: 10.1073/pnas.2322935121
Xue, Y.#, Zhang, Y.#, Zhong, Y.#, Du, S., Hou, X., Li, W., Li, H., Wang, S., Wang, C., Yan, J., Kang, D. D., Deng, B., McComb, D. W., Irvine, D. J., Weiss, R., Dong, Y.* LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing. Nature Communications (2024). DOI: 10.1038/s41467-024-45094-5
2023
Zhang, Y.#, Hou, X.#, Du, S., Xue, Y., Yan, J., Kang, D. D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.* Close the cancer-immunity cycle by integrating lipid nanoparticle-mRNA formulations and dendritic cell therapy. Nature Nanotechnology (2023). DOI: 10.1038/s41565-023-01453-9
Zhang, Y.#, Yan, J.#, Hou, X.#, Wang, C., Kang, D. D., Xue, Y., Du, S., Deng, B., McComb, D., Liu, S., Zhong, Y., Dong, Y.* STING agonist-derived LNP-mRNA vaccine enhances protective immunity against SARS-CoV-2. Nano letter (2023). DOI: 10.1021/acs.nanolett.2c04883
Du, S.#, Zhang, Y.#, Li, W.#, Xue, Y., Hou, X., Yan, J., Cheng, J., Deng, B., McComb, D., Lin, J., Zeng, H., Cheng, X., Irvine, D., Weiss, R., Dong, Y.* Cholesterol-amino-phosphate (CAP) derived lipid nanoparticles for delivery of self-amplifying RNA and restoration of spermatogenesis in infertile mice. Advanced Science (2023). DOI: 10.1002/advs.202300188
2022
Yan, J.#, Zhang, Y.#, Du, S.#, Hou, X., Li, W., Zhao, Y., Zeng, C., Zhang, C., Cheng, J., Deng, B., McComb, D., Zhao, W., Xue, Y., Kang, D. D, Cheng, X., Dong, Y.* Nanomaterials mediated co-stimulation of toll-like receptors and CD40 for antitumor immunity. Advanced Materials (2022). DOI: 10.1002/adma.202207486
Liu, J.#, Zhang, C.#, Zhang, X.#, Yan, J., Zeng, C., Talebian, F., Lynch, K., Zhao, W., Hou, X., Du, S., Kang, D. D, Deng, B., McComb, D., Bai, X.*, Dong, Y.* Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy. Journal of Controlled Release (2022). DOI: 10.1016/j.jconrel.2022.03.021
2021
Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.* Lipid nanopartices for mRNA delivery. Nature Reviews Materials (2021). DOI: 10.1038/s41578-021-00358-0
Zeng, C.#, Hou, X.#, Bohmer, M., Dong, Y.* Advances of nanomaterials‐based strategies for fighting against COVID‐19. VIEW (2021). DOI: 10.1002/VIW.20200180
Li, W.#, Zhang, X.#, Zhang, C.#, Yan, J.#, Hou, X., Du, S., Zeng, C., Zhao, W., Deng, B., McComb, D., Zhang, Y., Kang, D. D, Li, J., Carson, W., Dong, Y.* Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy. Nature Communications (2021). DOI: 10.1038/s41467-021-27434-x
Zhao, W.#, Zeng, C.#, Yan, J.#, Shi, D., Hou, X., Zhang, C., Li, W., Deng, B., McComb, D., Xue, Y., Kang, D. D., Dong, Y.* Construction of messenger RNA (mRNA) probes delivered by lipid nanoparticles to visualize intracellular protein expression and localization at organelles. Advanced Materials (2021). DOI: 10.1002/adma.202103131
2020
Zhao, P.#, Hou, X.#, Yan, J., Du, S., Xue, Y., Li, W., Xiang, G.*, Dong, Y.* Long-term storage of lipid-like nanoparticles for mRNA delivery. Bioactive Materials (2020). DOI: 10.1016/j.bioactmat.2020.03.001
Hou, X.#, Zhang. X.#, Zhao, W., Zeng, C., Deng B., McComb, D. W., Du, S., Zhang, C., Li, W., Dong. Y.* Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nature Nanotechnology (2020). DOI: 10.1038/s41565-019-0600-1
Hou, X., Zhang, W., Meng, Y., Zhou, W., Peng, G., Lei, J., Cong, S., Song, M., Li, G.*, Li, X.* A new anti-immune evasion strategy against methicillin-resistant Staphylococcus aureus infections: simulating complement immunotherapy based on complement-mimic antibiotic delivery system. Advanced Therapeutics (2020). DOI:10.1002/adtp.202000167
Zeng, C., Hou, X., Yan, J., Zhang, C., Li, W., Zhao, W., Du, S., Dong, Y.* Leveraging mRNA sequences and nanoparticles to deliver SARS-CoV-2 antigens in vivo. Advanced Materials (2020). DOI: 10.1002/adma.202004452
Zhang, S., Shrestha, C., Wisniewski, B., Pham, H., Hou, X., Li, W., Dong, Y., Kopp, B*. Consequences of CRISPR-Cas9-mediated CFTR knockout in human macrophages. Frontiers in Immunology (2020). DOI: 10.3389/fimmu.2020.01871
Zhang, X., Zhao, W., Nguyen, G., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., Deng, B., McComb, D., Dorkin, R., Shah, A., Barrera, L., Gregoire, F., Sign, M., Chen, D*., Sabatino, D*., Dong, Y.* Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing. Science Advances (2020). DOI: 10.1126/sciadv.abc2315
Li, B., Yan, J., Zhang, Y., Li, W., Zeng, C., Zhao, W., Hou, X., Zhang, C., Dong, Y.* CRISPR-Cas12a possess unconventional DNase activity that can be inactivated by synthetic oligonucleotides. Molecular Therapy-Nucleic Acids (2020). DOI: 10.1016/j.omtn.2019.12.038
2019
Zhao, W.#, Hou, X.#, Vick, O.G., Dong, Y.* RNA delivery biomaterials for the treatment of genetic and rare diseases. Biomaterials (2019). DOI: 10.1016/j.biomaterials.2019.119291
Zhang, Y.#, Zhang, X.#, Zeng, C., Li, B., Zhang, C., Li, W., Hou, X., Dong, Y.* Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR). Bioorganic & medicinal chemistry (2019). DOI: 10.1016/j.bmc.2019.04.019
Zhang, C., Zhao, W., Bian, C., Hou, X., Deng, B., McComb, D. W., Chen, X., Dong, Y.* Antibiotic-derived lipid nanoparticles to treat intracellular Staphylococcus aureus. ACS Appl. Bio Mater (2019). DOI: 10.1021/acsabm.8b00821
2018 and Prior
Zhang, X., Zhang, C., Yang, X., Hou, X., Zhao, W., Benson, D., Yu, J., Dong, Y.* Design, synthesis and evaluation of anti-CD38 antibody drug conjugate based on Daratumumab and Maytansinoid. Bioorganic & Medicinal Chemistry (2018). DOI: 10.1016/j.bmc.2018.12.024
Zhang, X., Zhao, W., Li, B., Li, W., Zhang, C., Hou, X., Jiang, J., Dong, Y.* Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice. Chemical Science (2018). DOI: 10.1039/c8sc03226b (HOT Chemical Science articles for September)
Peng, G., Hou, X., Zhang, W., Song, M., Yin, M., Wang, J., Li, J., Liu, Y., Zhang, Y., Zhou, W., Li, X.*, Li, G.* Alkyl rhamnosides, a series of amphiphilic materials exerting broad-spectrum anti-biofilm activity against pathogenic bacteria via multiple mechanisms. Artificial Cells, Nanomedicine, and Biotechnology (2018). DOI: 10.1080/21691401.2018.1491474
Meng, Y.#, Hou, X.#, Lei, J., Chen, M., Cong, S., Zhang, Y., Ding, W., Li, G.*, Li, X.* Multi-functional liposomes enhancing target and antibacterial immunity for antimicrobial and anti-biofilm against methicillin-resistant Staphylococcus aureus. Pharmaceutical Research (2016). DOI: 10.1007/s11095-015-1825-9
Ding, W., Li, Y., Hou, X., Li, G.* Bleomycin A6-loaded anionic liposomes with in situ gel as a new antitumoral drug delivery system. Drug Delivery (2016). DOI: 10.3109/10717544.2014.905651
Li, X., Hou, X., Ding, W., Cong, S., Zhang, Y., Chen, M., Meng, Y., Lei, J., Liu, Y.*, Li, G.* Sirolimus-loaded polymeric micelles with honokiol for oral delivery. Journal of Pharmacy and Pharmacology (2015). DOI: 10.1111/jphp.12482
Ding, W.#, Hou, X.#, Cong, S., Zhang, Y., Chen, M., Lei, J., Meng, Y., Li, X.*, Li, G.* Co-delivery of honokiol, a constituent of Magnolia species, in a self-microemulsifying drug delivery system for improved oral transport of lipophilic sirolimus. Drug Delivery (2015). DOI: 10.3109/10717544.2015.1020119